This approach has helped us in creating path-breaking brands.Įach patentedbrand at Troikaa has stemmed from original innovations of which the lead time from concept to commercialization has been effectively maintained from 6 to 10 years. Our R&D Department is approved by the Department of Scientific & Industrial Research, Government of India and has an innovation-driven approach. This helps in quick absorption of the drug and improves oral bioavailability.Ī) Strong portfolio of Patented Innovations: ![]() When the formulation is released into the lumen of the gut it disperses to form a fine emulsion so that the drug remains in solution in the gut, thereby offering very high surface area for absorption. SEDDS enables the formation of relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. SEDDS converts vitamin D3 into a soluble hydrophilic shell and improves its solubility. Furthermore, LiquiCaps disintegrate much faster as compared to softgels & hence release the active ingredient promptly on ingestion. The major benefits offered by LiquiCaps over soft gelatin capsules include lower microbial load in the thin gelatin shell of LiquiCaps, as compared to the heavy microbial burden in softgels. Nitrogen bubble in the LiquiCaps keeps active ingredient fresh and intact. LiquiCaps are 2-piece hard capsules, filled with oily medicaments & sealed with a band. Troyvit D3 LiquiCaps (Liquid-filled & sealed hard gelatin capsule), are formulated by SEDDS. To overcome this limitation and to bridge the gap, Troikaa has developed Troyvit D3, a formulation of Cholecalciferol capsules that utilizes the LiquiCaps technology with a Self Emulsifying Drug Delivery System (SEDDS). As Vitamin D is not completely miscible in water, it cannot be taken with water. Thus, small amounts of Vitamin C are released over a prolonged period of time from the matrix.Ĭholecalciferol (Vitamin D3) is a BCS – II vitamin with challenges to aqueous solubility which results in low dissolution and limits absorption. The Citrazinc SR tablets manufactured with this Matrix technology provide effective & desired outcomes in a controlled manner. The gel layer controls both the diffusion of water into the system and the diffusion of drug out of the system up to a desired period of time with a predetermined rate of release. ![]() When the matrix tablet is exposed to GI fluids, the surface of the tablet is wetted and the polymer hydrates to form a gel-like structure around the matrix. The mechanism of drug release from the matrix is based on the dissolution of the drug and its diffusion through the hydrated portion of the matrix. The active material is entrapped inside the matrix and is released slowly from the matrix. Citrazinc SR tablet was developed using matrix technology in which the drug, polymer and additional excipients are uniformly blended, granulated and then compressed into tablets. The Matrix technology used in Citrazinc SR facilitates release of small amounts of active ingredients, from the tablet in a controlled manner, over an extended period of time.
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